A genetic biomarker is described as a known DNA sequence that causes disease or is associated with susceptibility to disease. Using genetic biomarkers to predict the severity of a skin condition for a person as well as how that person is likely to respond to treatment would tremendously improve our ability to manage the disease for that patient. Precision health is about prescribing an individual patient with the right drug, at the right dose, at the right time. This would allow for earlier intervention and the increased potential to slow progression.
Inflammatory skin disease is an umbrella term that includes many distinct conditions. Within each of these, there is a spectrum of severity ranging from mild to severe. Many skin conditions typically go through periods of flare-up when symptoms are worsened, and periods of relative control of symptoms.
While inflammatory skin conditions manifest in the skin, over time they can have a wider effect on the body. For example, approximately one in three people with psoriasis will also develop pain and structural changes in their joints. Understanding why some people develop more extensive forms of the condition needs further investigation.
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